Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons

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Wang G, Guasp R, Salam S, Chuang E, Morera A, Smart AJ, Jimenez D, Shekhar S, Melentijevic I, Nguyen KC, Hall DH, Grant BD, Driscoll M. Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons. bioRxiv. 2023. Epub 20231116. doi: 10.1101/2023.11.13.565361. PubMed PMID: 38014134; PMCID: PMC10680645.

A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation

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Swords SB, Jia N, Norris A, Modi J, Cai Q, Grant BD. A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation. Autophagy. 2024;20(4):792-808. Epub 20231109. doi: 10.1080/15548627.2023.2269028. PubMed PMID: 37942902; PMCID: PMC11062384.

Barth Grant

Barth Grant, Ph.D.

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Syndapin and GTPase RAP-1 control endocytic recycling via RHO-1 and non-muscle myosin II

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Rodriguez-Polanco WR, Norris A, Velasco AB, Gleason AM, Grant BD. Syndapin and GTPase RAP-1 control endocytic recycling via RHO-1 and non-muscle myosin II. Curr Biol. 2023. Epub 20231005. doi: 10.1016/j.cub.2023.09.051. PubMed PMID: 37832552.

Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers

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Arnold ML, Cooper J, Androwski R, Ardeshna S, Melentijevic I, Smart J, Guasp RJ, Nguyen KCQ, Bai G, Hall DH, Grant BD, Driscoll M. Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers. Nat Commun. 2023;14(1):4450. Epub 20230724. doi: 10.1038/s41467-023-39700-1. PubMed PMID: 37488107; PMCID: PMC10366101.

Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell

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Wang Y, Arnold ML, Smart AJ, Wang G, Androwski RJ, Morera A, Nguyen KCQ, Schweinsberg PJ, Bai G, Cooper J, Hall DH, Driscoll M, Grant BD. Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell. Elife. 2023;12. Epub 20230302. doi: 10.7554/eLife.82227. PubMed PMID: 36861960; PMCID: PMC10023159.

Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points

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Norris A, McManus CT, Wang S, Ying R, Grant BD. Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points. PLoS Genet. 2022;18(10):e1010296. Epub 20221024. doi: 10.1371/journal.pgen.1010296. PubMed PMID: 36279308; PMCID: PMC9642905.

Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling

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Cooper JF, Guasp RJ, Arnold ML, Grant BD, Driscoll M. Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling. Proc Natl Acad Sci U S A. 2021;118(36). doi: 10.1073/pnas.2101410118. PubMed PMID: 34475208; PMCID: PMC8433523.

Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans

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Arnold ML, Cooper J, Grant BD, Driscoll M. Quantitative Approaches for Scoring in vivo Neuronal Aggregate and Organelle Extrusion in Large Exopher Vesicles in C. elegans. J Vis Exp. 2020(163). Epub 20200918. doi: 10.3791/61368. PubMed PMID: 33016946; PMCID: PMC7805482.

Endosomal microdomains: Formation and function

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Norris A, Grant BD. Endosomal microdomains: Formation and function. Curr Opin Cell Biol. 2020;65:86-95. Epub 20200401. doi: 10.1016/j.ceb.2020.02.018. PubMed PMID: 32247230; PMCID: PMC7529669.