The cells of our bodies are surrounded by a membrane that separates the molecules inside the cell from those on the outside. This membrane barrier provides cellular identity, and is essential for life as we know it, but it also represents a problem. How are large molecules that the cell needs to survive internalized? Likewise, how can the composition of the membrane be controlled to optimize the interaction of the cell with its environment? These fundamental issues of cellular function are solved in part by membrane traffic, the regulated movement of regions of membrane and their associated macromolecules using small carriers called vesicles. Our laboratory focuses on elucidating the underlying mechanisms that control these trafficking pathways in vivo.
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.
Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll.
Elife. 2024 Sep 10;13:RP95443. doi: 10.7554/eLife.95443.
RABR-1, an atypical Rab-related GTPase, cell-nonautonomously restricts somatosensory dendrite branching.
Christopher J Salazar, Carlos A Diaz-Balzac, Yu Wang, Maisha Rahman, Barth D Grant, Hannes E Bülow.
Genetics. 2024 Oct 7;228(2):iyae113. doi: 10.1093/genetics/iyae113.
LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α.
Sravanthi S P Nadiminti, Shirley B Dixit, Neena Ratnakaran, Anushka Deb, Sneha Hegde, Sri Padma Priya Boyanapalli, Sierra Swords, Barth D Grant, Sandhya P Koushika.
PLoS Genet. 2024 May 9;20(5):e1011253. doi: 10.1371/journal.pgen.1011253. eCollection 2024 May.
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.
Guoqiang Wang, Ryan Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll.
bioRxiv [Preprint]. 2024 Jun 10:2023.11.13.565361. doi: 10.1101/2023.11.13.565361.
A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
Sierra B Swords, Nuo Jia, Anne Norris, Jil Modi, Qian Cai, Barth D Grant.
Autophagy. 2024 Apr;20(4):792-808. doi: 10.1080/15548627.2023.2269028. Epub 2023 Nov 9.
Sep 10, 2024 - Co-authored paper with the Driscoll lab published in Elife. (PMID: 39255003)
Jul 19, 2024 - Co-authored paper with Buelow lab published in Genetics (PMID: 39028768). Congratulations Yu!
Jul 19, 2024 - Co-authored paper with Koushika lab published in PLoS Genetics (PMID: 38722918). Congratulations Sierra!
Jul 01, 2024 - Kam Shan Hu joined the lab as a Research Technician. Kam recently graduated with Highest Honors from the Rutgers Department of Molecular Biology and Biochemistry. She also received first place in the departmental Poster Contest and received the coveted Henry Rutgers Scholars Award.
Jun 04, 2024 - Barth presented our research at the Harvard Digestive Diseases Center (HDDC) Spring Symposium – Boston, MA
Apr 20, 2024 - Our paper co-authored with Cai lab published in Autophagy (PMID: 37942902). Congratulations Sierra and Anne!
Mar 20, 2024 - Barth presented our research at Texas A&M University, Department of Biochemistry
Jan 26, 2024 - Barth presented our research at University of Toronto, The Hospital for Sick Children (SickKids) Program in Cell Biology