Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.
Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll.
Elife. 2024 Sep 10;13:RP95443. doi: 10.7554/eLife.95443.
RABR-1, an atypical Rab-related GTPase, cell-nonautonomously restricts somatosensory dendrite branching.
Christopher J Salazar, Carlos A Diaz-Balzac, Yu Wang, Maisha Rahman, Barth D Grant, Hannes E Bülow.
Genetics. 2024 Oct 7;228(2):iyae113. doi: 10.1093/genetics/iyae113.
LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α.
Sravanthi S P Nadiminti, Shirley B Dixit, Neena Ratnakaran, Anushka Deb, Sneha Hegde, Sri Padma Priya Boyanapalli, Sierra Swords, Barth D Grant, Sandhya P Koushika.
PLoS Genet. 2024 May 9;20(5):e1011253. doi: 10.1371/journal.pgen.1011253. eCollection 2024 May.
Mechanical force of uterine occupation enables large vesicle extrusion from proteostressed maternal neurons.
Guoqiang Wang, Ryan Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll.
bioRxiv [Preprint]. 2024 Jun 10:2023.11.13.565361. doi: 10.1101/2023.11.13.565361.
A conserved requirement for RME-8/DNAJC13 in neuronal autophagic lysosome reformation.
Sierra B Swords, Nuo Jia, Anne Norris, Jil Modi, Qian Cai, Barth D Grant.
Autophagy. 2024 Apr;20(4):792-808. doi: 10.1080/15548627.2023.2269028. Epub 2023 Nov 9.
Syndapin and GTPase RAP-1 control endocytic recycling via RHO-1 and non-muscle myosin II.
Wilmer R Rodriguez-Polanco, Anne Norris, Agustin B Velasco, Adenrele M Gleason, Barth D Grant.
Curr Biol. 2023 Nov 20;33(22):4844-4856.e5. doi: 10.1016/j.cub.2023.09.051. Epub 2023 Oct 12.
Macrocephaly and developmental delay caused by missense variants in RAB5C.
Klaas Koop, Weimin Yuan, Federico Tessadori, Wilmer R Rodriguez-Polanco, Jeremy Grubbs, Bo Zhang, Matt Osmond, Gail Graham, Sarah Sawyer, Erin Conboy, Francesco Vetrini, Kayla Treat, Rafal Płoski, Victor Murcia Pienkowski, Anna Kłosowska, Elizabeth Fieg, Joel Krier, Coralie Mallebranche, Ziegler Alban, Kimberly A Aldinger, Deborah Ritter, Ellen Macnamara, Bonnie Sullivan, John Herriges, Joseph T Alaimo, Catherine Helbig, Colin A Ellis, Clare van Eyk, Jozef Gecz, Daniel Farrugia, Ikeoluwa Osei-Owusu, Lesley Adès, Marie-Jose van den Boogaard, Sabine Fuchs, Jeroen Bakker, Karen Duran, Zachary D Dawson, Anika Lindsey, Huiyan Huang, Dustin Baldridge, Gary A Silverman, Barth D Grant, David Raizen, Undiagnosed Diseases Network, Gijs van Haaften, Stephen C Pak, Holger Rehmann, Tim Schedl, Peter van Hasselt.
Hum Mol Genet. 2023 Oct 17;32(21):3063-3077. doi: 10.1093/hmg/ddad130.
Intermediate filaments associate with aggresome-like structures in proteostressed C. elegans neurons and influence large vesicle extrusions as exophers.
Meghan Lee Arnold, Jason Cooper, Rebecca Androwski, Sohil Ardeshna, Ilija Melentijevic, Joelle Smart, Ryan J Guasp, Ken C Q Nguyen, Ge Bai, David H Hall, Barth D Grant, Monica Driscoll.
Nat Commun. 2023 Jul 24;14(1):4450. doi: 10.1038/s41467-023-39700-1.
SPE-51, a sperm-secreted protein with an immunoglobulin-like domain, is required for fertilization in C. elegans.
Xue Mei, Katherine A Maniates, A'maya Looper, Amber R Krauchunas, Marina Druzhinina, Sunny Dharia, Julie Ni, Gunasekaran Singaravelu, Sam Guoping Gu, Diane C Shakes, Barth D Grant, Andrew W Singson.
Curr Biol. 2023 Jul 24;33(14):3048-3055.e6. doi: 10.1016/j.cub.2023.06.029. Epub 2023 Jul 14.
Conserved NIMA kinases regulate multiple steps of endocytic trafficking.
Braveen B Joseph, Naava Naslavsky, Shaonil Binti, Sylvia Conquest, Lexi Robison, Ge Bai, Rafael O Homer, Barth D Grant, Steve Caplan, David S Fay.
PLoS Genet. 2023 Apr 26;19(4):e1010741. doi: 10.1371/journal.pgen.1010741. eCollection 2023 Apr.
A Conserved Requirement for RME-8/DNAJC13 in Neuronal Autolysosome Reformation.
Sierra Swords, Nuo Jia, Anne Norris, Jil Modi, Qian Cai, Barth D Grant.
bioRxiv [Preprint]. 2023 Feb 28:2023.02.27.530319. doi: 10.1101/2023.02.27.530319.
Syndapin Regulates the RAP-1 GTPase to Control Endocytic Recycling via RHO-1 and Non-Muscle Myosin II.
Wilmer R Rodriguez-Polanco, Anne Norris, Agustin B Velasco, Adenrele M Gleason, Barth D Grant.
bioRxiv [Preprint]. 2023 Feb 28:2023.02.27.530328. doi: 10.1101/2023.02.27.530328.
Active zone protein SYD-2/Liprin-alpha acts downstream of LRK-1/LRRK2 to regulate polarized trafficking of synaptic vesicle precursors through clathrin adaptor protein complexes.
Sravanthi S P Nadiminti, Shirley B Dixit, Neena Ratnakaran, Sneha Hegde, Sierra Swords, Barth D Grant, Sandhya P Koushika.
bioRxiv [Preprint]. 2023 Feb 26:2023.02.26.530068. doi: 10.1101/2023.02.26.530068.
Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell.
Yu Wang, Meghan Lee Arnold, Anna Joelle Smart, Guoqiang Wang, Rebecca J Androwski, Andres Morera, Ken C Q Nguyen, Peter J Schweinsberg, Ge Bai, Jason Cooper, David H Hall, Monica Driscoll, Barth D Grant.
Elife. 2023 Mar 2;12:e82227. doi: 10.7554/eLife.82227.
Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points.
Anne Norris, Collin T McManus, Simon Wang, Ruochen Ying, Barth D Grant.
PLoS Genet. 2022 Oct 24;18(10):e1010296. doi: 10.1371/journal.pgen.1010296. eCollection 2022 Oct.
Stress increases in exopher-mediated neuronal extrusion require lipid biosynthesis, FGF, and EGF RAS/MAPK signaling.
Jason F Cooper, Ryan J Guasp, Meghan Lee Arnold, Barth D Grant, Monica Driscoll.
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):e2101410118. doi: 10.1073/pnas.2101410118.
The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.
Leo T H Tang, Meera Trivedi, Jenna Freund, Christopher J Salazar, Maisha Rahman, Nelson J Ramirez-Suarez, Garrett Lee, Yu Wang, Barth D Grant, Hannes E Bülow.
PLoS Genet. 2021 Jul 1;17(7):e1009475. doi: 10.1371/journal.pgen.1009475. eCollection 2021 Jul.